Summary

  • Id: L7N697
  • Locus: PE16_MYCTU
  • Protein Moltype: AA
  • Topology: linear
  • Definition: Esterase PE16
  • Organism: Mycobacterium tuberculosis H37Rv
  • Division: BCT
  • Update Date: 10-May-23
  • Create  Date: 16-Oct-19

The basic physicochemical properties calculated by ProtParam

Number of amino acids:
Molecular weight:
Theoretical pI:
Amino acid composition:


                            Total number of negatively charged residues (Asp + Glu): 
Total number of positively charged residues (Arg + Lys):
Atomic composition:

                            Formula: 
                            
Total number of atoms:
Estimated half-life:



                            Instability index:

                            



                            Aliphatic index:  
Grand average of hydropathicity (GRAVY):
Taxonomy:
Sequence:

The hydrophobicity information calculated by ProtScale

Using the scale Hydropath. / Kyte & Doolittle, the individual values for the 20 amino acids are:

                        

ProtScale output for L7N697

ProtScale graph

Subcellular Location

Prediction of subcellular localization using TBpred

Final Predicted Class Cytoplasmic Integral Membrane Secreted Attached to Membrane

Prediction of Signal Peptides and their cleavage sites in all domains of life using SignalP 6.0   

Prediction
Result
OTHER Sec/SPI
(Signal Peptide)
Sec/SPII
(Lipoprotein signal peptide)
Tat/SPI
(TAT signal peptide)
Tat/SPII
(TAT Lipoprotein signal peptide)
Sec/SPIII
(Pilin-like signal peptide)
Cleavage Site Position Probability

Plot of the predicted labels and probabilities of the sequence

Prediction of transmembrane helices in proteins using TMHMM - 2.0

len ExpAA First60 PredHel Topology

Secretory protein prediction result: Not secretory protein


Prediction of non-classical protein secretion using SecretomeP-2.0

Network 1 Network 2 Network 3 SecP score

Non-classical secretory protein prediction result: Non-classical secretory protein

Protein histidine phosphorylation sites prediction using PROSPECT

Protein function prediction using DeepGOPlus

Cellular Component

Molecular Function

Biological Process

Antigenicity Evaluation using VaxiJen

Homology between L7N697 and H. sapiens proteins (GRCh38.p14)

Toxicity prediction using Toxinpred 2

Allergenicity prediction using AllerTOP

Linear B-cell epitope prediction using ABCpred

MHC-I and MHC-II binding prediction using NetMHCpan-4.1 and NetMHCIIpan-4.0

MHC-I binding prediction result

Allele: HLA-A*01:01, high binders (%rank_EL<0.5): , weak binders (%rank_EL<2): , peptides:

Allele: HLA-A*02:01, high binders (%rank_EL<0.5): , weak binders (%rank_EL<2): , peptides:

Allele: HLA-A*03:01, high binders (%rank_EL<0.5): , weak binders (%rank_EL<2): , peptides:

Allele: HLA-A*24:02, high binders (%rank_EL<0.5): , weak binders (%rank_EL<2): , peptides:

Allele: HLA-B*07:02, high binders (%rank_EL<0.5): , weak binders (%rank_EL<2): , peptides:

MHC-II binding prediction result

Allele: DRB1_0101, high binders (%rank_EL<1): , weak binders (%rank_EL<5):

Allele: HLA-DPA10103-DPB10201, high binders (%rank_EL<1): , weak binders (%rank_EL<5):

Allele: HLA-DQA10102-DQB10501, high binders (%rank_EL<1): , weak binders (%rank_EL<5):

Allele: H-2-IAb, high binders (%rank_EL<1): , weak binders (%rank_EL<5):

Secondary Structure of Protein ( DSSP, NACCESS, NetSurfP-3.0 )

DSSP result

Position Amino acid Structure Structure details ACC TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA

NACCESS result

Position

All-atoms Total-Side Main-Chain Non-polar All-polar
ABS REL ABS REL ABS REL ABS REL ABS REL

NetSurfP-3.0 prediction result

Disorder Area

Homology proteins in MERITS

Tertiary structure Viewer (Source: AlphaFold DB)

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